Sender reputation filter must be enabled.

By performing filtering at the perimeter, up to 90% of SPAM, malware, and other undesirable messages are eliminated from the message stream rather than admitting them into the Mail server environment. Sender reputation is anti-SPAM functionality that blocks messages according to many characteristics of the sender. Sender reputation relies on persisted data about the sender to determine what action, if any, to take on an inbound message. This setting enables the sender reputation function.