The Exchange Outbound Connection Limit per Domain Count must be controlled.

Email system availability depends in part on best practice strategies for setting tuning configurations. This configuration controls the maximum number of simultaneous outbound connections from a domain as a delivery tuning mechanism. If the limit is too low, connections may be dropped. If the limit is too high, some domains may use a disproportionate resource share, denying access to other domains. Appropriate tuning reduces risk of data delay or loss. By default, a limit of 20 simultaneous outbound connections from a domain should be sufficient. The value may be adjusted if justified by local site conditions.